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Articles, Reports & PNI Press Releases
IMPROVEMENT IN MUCOSAL INTEGRITY AND FUNCTION IN IBD PATIENTS AND REDUCTION IN GI SYMPTOMS IN HIV PATIENTS WITH DIETARY PEPTIDES FROM HYDROLYZED WHITE FISH
Nichols TW, DelRossi J
Center for Nutrition and Digestive Disorders, Hanover, PA, USA
ABSTRACT (Regulatory Peptides. 2002;108(1):31)
Dietary peptides are known to have biological importance beyond their nutritive value as protein, influencing structural, immune, and gastrointestinal functions. The GI benefit of supplementation with a dietary bioactive peptide supplement prepared from hydrolyzed white fish was studied in two distinct populations in separate trials. In the first study, 15 IBD patients assessed to have gut mucosal hyperpermeability by a urine test utilizing lactose and mannitol ratios were given either 3g per day of the fish peptide supplement or a control for 6 weeks, followed by a second permeability test and symptom assessment scoring. Results with the IBD patients taking the supplement showed a trend towards improvement in both intestinal permeability and symptom assessment versus controls. We then hypothesized that if GI symptoms resulting from current recommended HIV therapy are associated with a similar inflammatory mechanism, these patients would also respond favorably to the peptide supplementation. Accordingly, a second population of 23 HIV-infected males experiencing GI side effects on highly active antiretroviral therapy (HAART) were given either 3g per day of the fish peptide supplement or a control for 5 months, with symptoms assessed before and after the treatment period. In the HIV patients, the number of GI symptoms collectively reported as decreased in the supplement group was significantly greater than the number of symptoms collectively reported as decreased in the control group. These bioactive peptides appear to have a dual function in HIV patients: controlling intestinal permeability as a potential long-term risk factor of HAART and reducing the GI side effects of HAART, which may relate to increased compliance and improved treatment outcome.
Preliminary reports: Improvement in mucosal integrity in IBD patients and reduction in GI symptoms in HIV patients with hydrolyzed white fish, by Trent W Nichols MD, Paul D Thomas DO, John DelRossi MPAS, PA-C, Angie Angstadt BS, and Barry W Ritz BS (Integrative Medicine 2003)
PROPER NUTRITION INCORPORATED
Founded in 1994 by Dr. Donald Snyder and headquartered in Reading, Pa., Proper Nutrition, Inc. is built on a record of innovation stretching back to the early 1960s, when Dr. Snyder, as the head of a U.S. Department of the Interior Fisheries Research Laboratory, led the charge against world hunger. At that time, protein deficiency was determined to be the most common and serious aspect of world hunger. Alarmed by starvation and malnutrition among third world nations, particularly among children and infants, many nations joined forces to launch a major worldwide humanitarian project to find an inexpensive source of protein to solve this problem. Dr. Snyder, as a member of a special committee of the U.S. National Academy of Sciences, was instrumental in developing an economically feasible method of providing protein to the world’s hungry.
A breakthrough came in the form of revolutionary FPC (Fish Protein Concentrate) technology, which allowed quality protein, retaining all of its original nutritional value, to be delivered to the body in a highly absorbable form. FPC was made available to the World Health Organization of the United Nations to aid in famine relief. Only after years of further testing and research were the additional healing benefits of this blending of science and nature discovered.
Today, Dr. Snyder and Proper Nutrition, Inc. offer revolutionary dietary supplements, including Intestive®, available directly to consumers; and SEACURE® and SEAVIVE®, professional products available for distribution by healthcare practitioners and retailers. Proper Nutrition’s current line of high quality nutritional supplements is the direct result of 40 years of research and refinement aimed at perfecting the FPC technology that was conducted by a highly skilled team of scientific experts. Derived from deep-ocean white fish, Proper Nutrition supplements offer proven alternatives for the support of the gastrointestinal tract and the promotion of immune system health. Further development and research is ongoing to extend the benefits of FPC technology to wound-healing and chemotherapy support supplements.
Intestive®, the first of Proper Nutrition’s consumer products, is specially formulated with all-natural ingredients to promote complete gastrointestinal health. Intestive® is a safe, effective and drug-free alternative for mitigating the symptoms commonly associated with Irritable Bowel Syndrome (IBS). IBS symptoms involve chronic or recurrent abdominal pain, the sudden and urgent need to go to the bathroom, bloating, and frequent diarrhea or constipation. The number of people in the U.S. suffering from IBS has been estimated to be as high as one in five.
For additional questions or consumer information please call (800) 555-8868 Monday-Friday, 9AM-5PM EST or visit www.propernutrition.com. To place an order by phone 24 hours/day, please call (800) 247-5656 or visit www.propernutrtion.com.
READING, PA. — Proper Nutrition, Inc. this week announced the release of Intestive®, a new clinically tested, side effect-free, all-natural treatment for Irritable Bowel Syndrome (IBS), a chronic disorder affecting millions of Americans. Intestive® contains Seacure®, a fish protein concentrate originally developed by scientists 40 years ago for use by the World Health Organization to fight famine-related gastrointestinal problems around the world.
IBS affects at least one out of five people in the United States1, and afflicts three times as many women as men2. Symptoms involve chronic or recurrent abdominal pain, the sudden and urgent need to go to the bathroom, frequent diarrhea or constipation, and bloating. IBS is an ongoing problem, and while it is not fatal, the chronic discomfort and acute embarrassment of IBS hamper the lives of millions of Americans every day, hindering social outings, regular work schedules, and family time. IBS is also known as spastic colon, spastic bowel, functional bowel disease, and nervous stomach. While there is no cure for IBS, recent developments in the management of IBS symptoms promise a greatly improved quality of life for IBS sufferers.
Intestive® is the latest breakthrough in the management of IBS. Intestive® gives IBS sufferers a chance to take control of their lives again by effectively alleviating IBS symptoms, safely and comprehensively. In addition to relieving chronic diarrhea and constipation, Intestive® also fosters a healthy intestinal lining and improves overall bowel function dramatically. While proteins are essential to a healthy diet, complex proteins are often difficult to absorb. Because Intestive® contains high-levels of bio-active peptides and amino acids — proteins in their simplest forms — it is easily absorbed by the body. Intestive® helps to maintain the body’s delicate balance and regulate gastrointestinal health at a cellular level by supplying proteins that have been broken into their basic building blocks, yet retain all of their nutritional value.
Intestive® is the effective all-natural alternative to prescription or over-the-counter remedies, which often alleviate only some of the symptoms experienced by IBS sufferers. Moreover, Intestive® produces none of the side effects — such as constipation and intestinal pain — sometimes associated with other treatments for gastrointestinal problems.
In addition to the concentrated bio-active peptides and amino acids that make Intestive® so effective, this new supplement also supplies boswellia, a natural anti-inflammatory; colostrum, free of caseine and lactose, to fight infection; and omega-3 fatty acids.
"Americans eat plenty of protein, but it isn’t always the right kind to maintain a healthy internal balance. For years, we’ve known that eating fish may help us to resist colitis, arthritis, heart disease and a host of other health problems," explains Dr. Donald Snyder. "Essential fatty acids and other important nutritional requirements are found in fish, in a form that our bodies can easily absorb. Intestive® helps a body suffering from IBS to achieve a healthy balance and maintain it."
Intestive® is currently available only through the Proper Nutrition Web site at www.propernutrition.com or by phone at (800) 247-5656. Based on clinical studies, Proper Nutrition has launched a program to develop the applications of the Seacure® concentrate used in Intestive®, extending its benefits to other health issues. For more information on Intestive® or Proper Nutrition, call (800) 555-8868 or visit www.propernutrition.com.
1. Irritable Bowel Syndrome & The Mind-Body/Brain-Gut Connection, William B. Salt II, MD; Parkview Publishing, 1998.
2. Knight Ridder Newspapers, 2000.
With public concern mounting about side effects from treatments for Irritable Bowel Syndrome (IBS), many IBS sufferers are turning to all-natural, drug-free remedies, like new Intestive® from Proper Nutrition, Inc., for the support of gastrointestinal health. Intestive® is a breakthrough in promoting healthy gastrointestinal and bowel function, without inconvenient or uncomfortable side effects. Intestive® is the effective all-natural alternative to prescription or over-the-counter remedies.
In fact, the primary ingredient in Intestive®, SEACURE®, a 100% white fish protein concentrate, has a long history of safe and effective use. Developed by scientists 40 years ago, for use in fighting worldwide famine, SEACURE® has resulted in no reported cases of side effects or adverse reactions, even among infants. A recently published initial study demonstrates the protein concentrate’s effectiveness in reducing IBS symptoms. Furthermore, the two additional active ingredients in Intestive®, colostrum (free of casein and lactose) and boswellia, are all-natural products known to be safe and effective.
Intestive® is currently available only through the Proper Nutrition Web site at www.propernutrition.com or by phone at (800) 247-5656. For more information on Intestive® or Proper Nutrition, call (800) 555-8868 or visit www.propernutrition.com.
In an election year, when big pharmaceutical companies are lining the pockets of legislators, the health of Americans may be in jeopardy. According to an article in The Wall Street Journal this week, "The Food and Drug Administration is reviewing a handful of deaths and several dozen unusual side effects in patients who had taken [a pharmaceutical drug] to treat irritable bowel syndrome."
A difficult and embarrassing affliction to discuss with friends or even healthcare professionals, Irritable Bowel Syndrome (IBS) affects nearly 20 percent of the population – more than 55 million Americans. Although IBS does not have big-name star power pushing for a solution – as Katie Couric does for colon cancer, Michael J. Fox does for Parkinson’s Disease or Rosie O’Donnell does for breast cancer – it is an urgent issue for one out of five Americans.
The good news is that IBS sufferers now have a safe, effective alternative to pharmaceutical drugs. An all-natural, drug-free remedy, Intestive® from Proper Nutrition, Inc., is a breakthrough in promoting gastrointestinal health and bowel function, without the inconvenient, uncomfortable or life-threatening side effects. In fact, the primary ingredient in Intestive®, SEACURE®, a 100% white fish protein concentrate, has been used safely and effectively for more than 40 years. Developed by scientists for use in fighting worldwide famine, SEACURE® has resulted in no reported cases of side effects or adverse reactions, even among infants. And, a recently published initial study demonstrates that the new SEACURE®-based product Intestive® was effective in improving general health in just under 85% of patients in as little as 30 days. Furthermore, the two additional active ingredients in Intestive®, colostrum (free of casein and lactose) and boswellia, are all-natural products known to be safe.
Intestive® is currently available only through the Proper Nutrition Web site at www.propernutrition.com or by phone at (800) 247-5656. For more information on Intestive® or Proper Nutrition, call (800) 555-8868 or visit www.propernutrition.com.
SAFE, EFFECTIVE ALTERNATIVE TO PRESCRIPTION IBS DRUG
IBS Sufferers Reliant on Withdrawn Pharmaceutical Treatment Can Turn to All-Natural Solution
This week, pharmaceutical giant Glaxo Wellcome, Inc. announced the withdrawal of Lotronex, a pharmaceutical drug for the treatment of Irritable Bowel Syndrome (IBS), bringing to the forefront this disorder that affects as many as 55 million American adults yet is virtually unknown to the public. According to the International Foundation for Functional Gastrointestinal Disorders (IFFGD), IBS is the second leading cause of illness-related absenteeism from work or school (second only to the common cold) and the most common disease diagnosed by gastroenterologists. Physicians cite IBS as one of the top 10 most frequent diagnoses nationally, yet this widespread gastrointestinal disorder remains a hidden malady.
A difficult and embarrassing affliction to discuss with friends or even healthcare professionals, Irritable Bowel Syndrome (IBS) affects approximately 15-20 percent of the American population. Although IBS does not have big-name star power pushing for a solution – as Katie Couric does for colon cancer, Michael J. Fox does for Parkinson’s Disease or Rosie O’Donnell does for breast cancer – it is an urgent issue for one out of five Americans. With the withdrawal from market of the controversial pharmaceutical IBS treatment, sufferers must now look elsewhere to maintain their health and quality of life, an especially critical issue during this holiday season. While the exact causes of IBS have yet to be determined, holiday stress and rich holiday foods are sure to be IBS triggers for many.
The good news is that IBS sufferers now have a safe, effective alternative to pharmaceutical drugs. An all-natural, drug-free remedy, Intestive® from Proper Nutrition, Inc. is a breakthrough in promoting gastrointestinal health and bowel function, without the inconvenient, uncomfortable or life-threatening side effects. In fact, the primary ingredient in Intestive®, SEACURE®, a 100 percent white fish protein concentrate, has been used safely and effectively for more than 40 years. Developed by scientists for use in fighting worldwide famine, SEACURE® has resulted in no reported cases of side effects or adverse reactions, even among infants. And, a recently published initial study demonstrates that the new SEACURE®-based product Intestive® was effective in improving general health in just under 85 percent of patients in as little as 30 days. Furthermore, the two additional active ingredients in Intestive®, colostrum (free of casein and lactose) and boswellia, are all-natural products known to be safe.
Intestive® is currently available only through the Proper Nutrition Web site at www.propernutrition.com or by phone at (800) 247-5656. For more information on Intestive or Proper Nutrition, or to arrange an interview with a Proper Nutrition spokesperson, please contact (800) 555-8868 or visit www.propernutrition.com.
Reading, PA – Proper Nutrition, Inc., has announced the release of Colostrum 80/40™, a hyperimmune bovine colostrum product concentrated through advanced fermentation and ultrafiltration techniques to deliver the highest immunoglobulin G (IgG) content available on the market, without the casein and lactose.
IgG is an antibacterial, antitoxic, and antiviral protein, and is the principal immune factor naturally present in colostrum. Proper Nutrition’s Colostrum 80/40™ is concentrated through the removal of fat, casein, and and lactose to contain a minimum of 80% protein and 40% IgG by total dry weight. Many colostrum producers claim 40% IgG, meaning that 40% of the protein is in the form of IgG, which can translate into as little as 20% of the total colostrum in each capsule. Colostrum 80/40™ provides 40% IgG by total dry weight.
Proper Nutrition’s Colostrum 80/40™ is specially prepared to remove the casein and lactose normally present in whole colostrum and tested to confirm that the final product contains less than 1% casein and less than 1% lactose by dry weight. Finally! Colostrum 80/40™ delivers the immune-supportive benefits of colostrum to the hundreds of thousands of people who need to avoid casein and/or lactose as a result of food intolerances and allergies.
Proper Nutrition is your source for colostrum products of U.S. origin, and Colostrum 80/40™ is your answer to high quality colostrum without the casein and lactose. Proper Nutrition colostrum products are available to health care professionals and retailers at 800-735-2051. For more information, visit www.propernutrition.com or call Proper Nutrition at 800-555-8868. Product photos available.
NORTH AMERICA’S LARGEST SUPPLIER OF COLOSTRUM—IT’S NOT WHO YOU THINK
Reading, PA – Proper Nutrition, Inc., maker of Seacure® hydrolyzed white fish dietary supplement, has unveiled a line of high-quality colostrum products in cooperation with La Belle, Inc., North America’s largest supplier of colostrum.
The bovine colostrum is from dairy herds of U.S. origin only, fed diets free of animal by-products, as well as free of antibiotics, hormones, and pesticides. Proper Nutrition does not use colostrum from European or New Zealand sources. Proper Nutrition’s colostrum is produced in state-of-the-art, licensed food processing facilities in Washington and California. These facilities follow GMP procedures and are USDA inspected.
Proper Nutrition has introduced Colostrum 80/40™, the only colostrum product on the market specially prepared to remove the fat, casein, and lactose. Colostrum 80/40™ provides the highest level of immunoglobulin G (IgG) available in any colostrum product.
or Immediate Release January 3, 2003
Contact: Barry W. Ritz 800-555-8868 barry@propernutrition.com
In Memorium: Donald G. Snyder, PhD
Reading, PA- Proper Nutrition, Inc., regrets to announce that Dr. Donald Snyder passed away on December 25 at the age of 76. “Doc” Snyder founded Proper Nutrition, Inc., in 1994, and served as the company’s CEO.
Doc received his PhD in biochemistry and nutrition from Georgetown in 1957. His career included various positions as a government employee until 1969 and as an independent consultant from 1969-1994. He served as Director of the Fisheries Technological Laboratory of the Department of the Interior and was involved with such organizations as the Food and Nutrition Board of the United Nations, the National Academy of Sciences, and the National Research Council. He played an integral role in the development of fish protein concentrate to combat world malnutrition and established Proper Nutrition, Inc., in 1994, to market one such fish protein concentrate as Seacure® for its clinical applications.
Doc was a World War II veteran and enjoyed playing the trumpet in his Big Band. He had an unceasing sense of humor and a knack for telling stories and jokes. He will be greatly missed, although his contributions to nutrition science remain ever present.
Reading, PA—Proper Nutrition, Inc., announces that its specialty dietary supplement Seacure® used to support intestinal health and healing will be available to veterinarians and pet owners under a pet label on August 1, 2003.
This new packaging comes in response to overwhelming satisfaction from consumers and holistic vets who have been sharing the human dietary supplement with their pets. Seacure® for pets complies with product labeling regulations for pet supplementation, including clear dosing instructions for animals.
Seacure® hydrolyzed white fish has been used successfully as a human dietary supplement for over 40 years, with its roots in efforts to quench world malnutrition led by the late Dr. Donald Snyder. A high-quality protein supplement, Seacure® supports digestion and healthy skin & coat in animals. Dogs and cats enjoy the white fish flavor.
Electronic photo available upon request.